Published: Tue, January 24, 2017
World | By Tasha Manning

Revolutionary study demonstrates dramatic histopathological changes with Stretta and Secca

Revolutionary study demonstrates dramatic histopathological changes with Stretta and Secca

Randomized Study Shows Non-Ablative Radiofrequency Treatment Promotes Smooth Muscle Regeneration and May Encourage Nerve Regeneration NORWALK, Conn., Oct. 22 / PRNewswire-USNewswire / - December 2014 / PRNewswire / - A recently published, blinded pathologist study examining changes in histopathology after non-ablative radiofrequency (NARF) for smooth muscle provided by Stretta therapy for GERD and Secca therapy for incontinence Fecal Radiofrequency therapy is commonly thought in terms of ablation, where tissue destruction occurs. In contrast, this study shows that this type of radiofrequency (NARF) unique low-power, low non-ablative temperature improves the smooth muscle sphincters of the gastrointestinal tract as well as the skeletal muscle of the external anal sphincter. The research confirms multiple mechanisms that can regenerate and improve the function of treated sphincter muscles, with improved symptoms of patients suffering from these debilitating diseases.

Infographic - http: //photos.prnewswire. This study documented the following advantages of NARF in the presence of a compromised sphincter:

Hypertrophy of smooth and skeletal muscle fibers

Smooth muscle size and muscle package increase Decreased Cajal interstitial cells (ICCs) Collagen I synthesis An increase in the proportion of collagen I / collagen III Fibrosis is reduced, due to a regression of excessive collagen deposition Similar effect in type I and II fibers as Reinnervation (nerve regrowth)

The randomized study was performed in an animal model of fecal incontinence with three arms of study: an experimental model of fecal incontinence with sphincter muscle damage, which remained untreated; A group with sphincter damage, treated with NARF; A control group without a damaged and untreated sphincter. After 10 weeks the treated tissue was suppressed and preserved. The resulting H & E and portions of tricroma were examined by two pathologists, who were guided to the origin of the tissue sample. The lead author of the study, Dr. Mariana Berho, director of the Pathology and Laboratory Medicine Center and the Center for Research at Cleveland Clinic Florida and a consultant at Mederi Therapeutics Inc. explained: "The results of this model study Animal studies are extremely valuable as they may reflect the changes occurring in the human lower esophageal sphincter as well as the internal anal sphincter after administration of the radiofrequency. "

This research concluded that non-ablative radiofrequency Appeared to induce deep morphological changes in the sphincter muscle leading to an anatomical state reminiscent of the sphincter's base structure. In addition, muscle regeneration explains how NARF, Stretta and Secca therapies work to improve the symptoms that accompany GERD and fecal incontinence.

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The study was published online in Colorectal Disease, visit http: // dx

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