Published: Tue, February 21, 2017
World | By Tasha Manning

Pancytopenia - Definition, Symptoms, and Treatments

Pancytopenia - Definition, Symptoms, and Treatments

What is pancytopenia, what are the symptoms, what causes it, and how is it treated? Pancytopenia is defined as abnormally low levels of all types of blood cells produced by the bone marrow.

. This includes red blood cells, white blood cells, and platelets.

Blood Cells Affected in Pancytopenia

Specifically, pancytopenia refers to a deficiency of:

  • Red blood cells (RBCs) - What bind and carry oxygen to the tissues of the body.
  • White blood cells (WBCs) - There are several types of white blood cells (WBCs) which are further broken down Into granulocytes: neutrophils, eosinophils, and basophils, and agranulocytes: lymphocytes and monocytes. Describing Low Levels of Blood Cells
  • H3> Formation of Blood Cells in the Bone Marrow - Hematopoiesis

    Blood cells all originate from a single common cell in the bone marrow, know as a hematopoietic stem cell (HSM.) These cells divide and become progressively more Specialized in a process called hematopoiesis into all of the blood cells in the body.

    Lab Tests

    Pancytopenia is usually diagnosed by looking at full blood count (CBC.) Results will show A blood cell count of less than 4.2 million cells / cc in women or less than 4.7 million cells / cc in men (This may also be described by A low hemoglobin level.)

  • A white blood count less than 4,000 cells / cc (normal is between 4,000 and 10,000 cells / Platelet count less Causes of Pancytopenia

This may involve bone marrow destruction by toxins, bone marrow suppression, such as during chemotherapy, or The replacement of bone marrow by other cells resulting in the disruption of blood cell production can occur with some cancers. Destruction or suppression may occur from inflammation , infections , autoimmune conditions.

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Most of these conditions are acquired later in life, but a few are inherited and present from birth. At least 50 percent of the time there is no obvious cause-something doctors refer to the "idiopathic ." Some of the possible causes may include:

Chemotherapy-induced bone marrow suppression Drug induced - Drugs other than chemotherapy drugs, Have been cited as causes. Infections such as infectious mononucleosis and HIV, as well as overwhelming infections (sepsis.)
  • Aplastic anemia.
  • Splenic sequestration (holding of blood cells in the spleen so they can not get to the rest of the body.)
  • Toxins and chemical exposure such as exposure to arsenic or benzene. Myelodysplastic syndrome (a "pre-cancerous" condition of the bone)
  • Blood cancers in the bone marrow such as leukemia, lymphoma, myeloma, or metastatic cancer to bone marrow. Marrow.)
  • Autoimmune disorders such as lupus.
  • Radiation sickness.
  • Inherited syndromes, such as Fanconi anemia, Most common Causes of pancytopenia

    A 2014 study set out to determine the most common causes of pancytopenia in people who were not already diagnosed with a condition.

    The symptoms of pancytopenia may include weakness, seizures, or enlarged spleen in addition to symptoms related to deficiency of specific blood cells. Some of these symptoms include:
  • Symptoms related to anemia (a low blood cell count) including pallor, fatigue, rapid heart rate, and shortness of breath. Related to leukopenia or neutropenia (a low white count) including fever and signs of infection such as cough or pain with urination
  • Symptoms related to thrombocytopenia (low platelets) including easy bruising, and heavy bleeding.

Diagnosis and Evaluation of Pancytopenia

After repeating your work to confirm that you truly have pancytopenia, P> bone marrow biopsy report can give your doctor a lot of information.

Treatment of pancytopenia

The goal in treating pancytopenia is to find and treat the underlying cause. If the cause is not known, or if it is expected, such as with chemotherapy, treatment is aimed at minimizing the symptoms related to the deficiency of the blood cells. Prognosis

The prognosis of pancytopenia largely depends on its cause. Dan developed pancytopenia-a low.

Example: Dan developed pancytopenia-a low Level of red blood cells, white blood cells, and platelets-after his last chemotherapy treatment. Devitt, K., Lunde, J., and M. Lewis. New Onset Pancytopenia in Adults: A Review of Underlying Pathologies and Their Associated Clinical and Laboratory Findings. Leukemia and Lymphoma . 2014. 55 (5): 1099-105.

Miano, M., and C. Dufour. The diagnosis and treatment of aplastic anemia: a review. International Journal of Hematology . 2015. 101 (6): 527-35.

Weinzierl, E., and D. Arber. The differential diagnosis and bone marrow evaluation of new-onset pancytopenia. American Journal of Clinical Pathology . 2013. 139 (1): 9-29.

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