Published: Mon, February 06, 2017
World | By Tasha Manning

Tegretol | Definition of Tegretol by Medical Dictionary

Tegretol | Definition of Tegretol by Medical Dictionary

Carbamazepine (CA), Carbamazepine (CA), Carbamazepine (CA), Carbamazepine (CA), Carbamazepine (CA), Carbamazepine (CA), Carbamazepine ), Epitol, Equetro, Gen-Carbamazepine (CA) Mazepine (CA), Novo-Carbamazepine (CA), Nu-Carbamazepine (CA), PHL-Carbamazepine (CA), PMS-Carbamazepine (CA), Sandoz Carbamazepine Tegretol, Tegretol-XR Pharmacologic class: Iminostilbene derivative

Therapeutic class Anticonvulsant

Pregnancy risk category / H3>

• Prescriber should be closely familiar with prescribing information, particularly regarding use with other drugs (especially those that increase toxicity potential).

• Drug has been linked to aplastic anemia and agranulocytosis. / P>

• Transient or persistent decreases in platelet or white blood cell (WBC) counts have occurred, but data are not available to accurately estimate incidence or outcome. Rarely, leukopenia cases progressed to aplastic anemia or agranulocytosis.

• Obtain complete pretreatment hematologic tests as baseline. If WBC or platelet count drops during therapy, monitor closely.

Capsules (extended-release) : 100 mg , 200 mg, 300 mg

Oral suspension : 100 mg / 5 ml Tablets : 200 mg

Tablets (chewable) : 100 mg

Tablets (extended-release) : 100 mg, , 400 mg

Indications and dosages

➣ Prophylaxis of generalized tonic-clonic, mixed, and complex-partial seizures

Children ages 6 to 12: Initially, 100 mg P.O. B.i.d. (Tablets) or 50 mg q.i.d. (Oral suspension). Increase by up to 100 mg weekly until therapeutic levels are reached. Usual maintenance dosage is 400 to 800 mg / day. Do not exceed 1 g / day. Give extended-release forms b.i.d.

Children younger than age 6: Initially, 10 to 20 mg / kg / day P.O. In two or three divided doses. May increase by up to 100 mg / day at weekly intervals. Usual maintenance dosage is 250 to 350 mg / day. Do not exceed 400 mg / day.

Adverse reactions

CNS: ataxia, drowsiness, fatigue, psychosis, syncope , Vertigo, headache, worsening of seizures CV: hypertension, hypotension, arrhythmias, atrioventricular block, aggravation of coronary artery disease, heart failure P>

EENT: blurred vision, diplopia, nystagmus, corneal opacities, conjunctivitis, pharyngeal dryness GI: nausea, vomiting, diarrhea, Abdominal pain, stomatitis, glossitis, dry mouth, anorexia

GU: urinary hesitancy, retention, or frequency; albuminuria; Glycosuria; Erectile dysfunction

Hematologic: eosinophilia, lymph-adenopathy, agranulocytosis, aplastic anemia, thrombocytopenia, leukopenia : Syndrome of inappropriate antidiuretic hormone secretion

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Skin: photosensitivity, rash, urticaria, diaphoresis, erythema multiforme, Stevens- Johnson syndrome / P>

Anticoagulants, bupropion : increased metabolism of these drugs, decreased risk of acetaminophen-induced hepatotoxicity, decreased acetaminophen efficacy Efficacy

Charcoal : decreased carbamazepine absorption : decreased barbiturate blood level, increased carbamazepine blood level

Cimetidine, danazol, diltiazem : increased carbamazepine blood level

Doxycycline : shortened doxycycline half-life and reduced antimicrobial effect

Hormonal contraceptives : decreased contraceptive efficacy, possibly leading to pregnancy

Isoniazid : increased risk of carbamazepine toxicity and isoniazid hepatotoxicity

Hydantoins : increased or decreased hydantoin blood level, decreased carbamazepine (P <0.05). In the present study, the use of progestogen-selective serotonin reuptake inhibitors (such as fluoxetine and flu-voxamine), macrolide antibiotics (such as clarithromycin and erythromycin) : increased carbamazepine blood level, greater risk of toxicity

MAO inhibitors : high fever, hypertension, seizures, and possibly death

Nondepolarizing neuromuscular blockers : shortened carbamazepine duration of action

TCAs : increased carbamazepine blood level and greater risk of toxicity, decreased TCA blood level

Valproic acid : Decreased blood pressure with possible loss of seizure control, variable changes in carbamazepine blood level

Drug-diagnostic tests Blood urea nitrogen, eosinophils, liver function tests

Drug-food : increased values ​​

Granulocytes, hemoglobin, platelets, thyroid function tests, Grapefruit juice : increased drug blood level and effects

Drug-herbs Plantain (psyllium seed) >: Inhibited GI absorption of drug

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